Viewing data from:

PROMETHEGAN

ANDA

PROMETHAZINE HYDROCHLORIDE | A087165 | COSETTE PHARMACEUTICALS NC LABORATORIES LLC

1 strength0 unique patents0 unique exclusivities

Drug Pricing (NADAC)

National Average Drug Acquisition Cost — Week of 2026-07-15 | 1 NDC

Highest NADAC/Unit

$24.54

per ea

Lowest NADAC/Unit

$24.54

per ea

Brand NDCs

Generic NDCs

NDC Description	NADAC/Unit	Unit	Type	Generic NADAC	Effective
00713013212PROMETHEGAN 50 MG SUPPOSITORY	$24.54	EA	Generic	—	2026-03-18

Source: NADAC (data.medicaid.gov). Prices reflect national average acquisition costs for retail community pharmacies.

VA Federal Supply Schedule

Government-negotiated contract prices | 1 NDC (1 FSS)

Lowest Price

$290.00

Highest Price

$290.00

FSS NDCs

Big4 NDCs

Description	Price	Type	Vendor	Contract End
00713-0132-12PROMETHAZINE HCL 50MG SUPP,RTL	$290.00	FSS	Cosette Pharmaceutical, Inc.	08/14/2027

Source: VA Federal Supply Schedule (va.gov). Prices are government-negotiated contract prices.

Medicare Part D Spending

CMS annual spending data for Promethegan (2024)

Total Spending

$1.9M

Total Claims

18,532

Beneficiaries

12,149

Avg Cost/Unit

$5.04

Spending Trend

$2.3M(2019)→$2.7M(2020)→$2.7M(2021)→$2.6M(2022)→$3.2M(2023)→$1.9M(2024)

YoY Change:-31.4%

5yr CAGR:-10.0%

Source: CMS Medicare Part D Spending by Drug (2024). Shows gross drug cost under Part D.

API Supply Chain3 active DMFs5 inactive

3 active API suppliers hold Drug Master Files for this ingredient.

ZYDUS LIFESCIENCES LTDPROMETHAZINE HYDROCHLORIDE USP

DMF 198402006

EMCURE PHARMACEUTICALS LTDPROMETHAZINE HYDROCHLORIDE USP

DMF 258062012

AREVA SYNTHETICS LLCPROMETHAZINE HYDROCHLORIDE USP

DMF 421762025

PHENCHEM INDUSTRIES LTDInactivePROMETHAZINE HYDROCHLORIDE

DMF 19741972

MAY AND BAKER LTDInactivePROMETHAZINE HYDROCHLORIDE

DMF 94051991

SIGMA ALDRICH IRELAND LTDInactivePROMETHAZINE HYDROCHLORIDE

DMF 118881996

WANBURY LTDInactivePROMETHAZINE HYDROCHLORIDE

DMF 181732005

IPCA LABORATORIES LTDInactivePROMETHAZINE HYDROCHLORIDE USP

DMF 272412013

Source: FDA Drug Master Files (fda.gov). Type II API DMFs matched by ingredient.

Products (1)

#001 — 50MG

0 patents0 exclusivities▴

SUPPOSITORY;RECTAL | Approved: Aug 14, 1987

No patent or exclusivity listings for this strength.