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DEXTENZA

NDA

DEXAMETHASONE | N208742 | OCULAR THERAPEUTIX INC

1 strength5 unique patents1 unique exclusivity

Patent Timeline

5 unique patents, 1 exclusivity by expiration date

Active (5)TodayExclusivity

2026

2027

2028

2029

2030

2031

2032

2033

2034

2035

2036

2037

2038

2039

2040

2041

2042

Today

May. 14, 2030

Feb. 12, 2030

Nov. 16, 2037

Apr. 26, 2041

Oct. 7, 2036

NPP

Apr. 7, 2028

PTAB Proceedings

No IPR/PGR/CBM challenges found at the Patent Trial and Appeal Board

Patent Reexaminations

No ex parte or inter partes reexamination proceedings found at USPTO

Hatch-Waxman Litigation

1 case on OB patents from PACER

Case	Court	Filed	Status	Judge
Ocular Therapeutix, Inc. v. Mati Therapeutics, Inc. 1:2018cv01991	D. Del.	2018-12-14	Terminated 2019-04-29	—

Source: PACER. NOS 835 (Patent - Abbreviated New Drug Application).

Citizen Petitions

No FDA citizen petitions matched from Regulations.gov

Clinical Trials

500 trials from ClinicalTrials.gov, 111 active, 389 completed

Trial	Phase	Status	Sponsor	Enrollment	Dates
A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to Daratumumab NCT04302324	Phase 2	Active	Weill Medical College of Cornell University	11	2021-10-28 → 2027-12-28
Elotuzumab, Pomalidomide, & Dexamethasone (Elo-Pom-Dex) With Second Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma NCT03030261	Phase 2	Active	Washington University School of Medicine	25	2017-11-22 → 2027-09-26
Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma NCT02436707	Phase 2	Active	Canadian Cancer Trials Group	129	2015-10-27 → 2026-12-31
Study of SubQ Dara With Dose-Attenuated Bortezomib, Lenalidomide, Dexamethasone in Elderly NDMM NCT04052880	Phase 2	Active	Larysa Sanchez	17	2019-10-24 → 2026-05
Study Comparing Continuous Versus Fixed Duration Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma NCT03836014	Phase 3	Active	Assistance Publique - Hôpitaux de Paris	436	2019-07-25 → 2026-07
Trial of Immunomodulatory Therapy in High Risk Solitary Bone Plasmacytoma NCT02544308	Phase 3	Active	University College, London	36	2017-03-10 → 2026-12
A Study of Elotuzumab With Pomalidomide, Bortezomib, and Dexamethasone in Relapsed Multiple Myeloma NCT02718833	Phase 2	Active	Massachusetts General Hospital	52	2016-06-21 → 2027-12
Phase II Study of IRD (Ixazomib, Lenalidomide, Dexamethasone) Post Autologous Stem Cell Transplantation Followed by Maintenance Ixazomib or Lenalidomide for Multiple Myeloma NCT02253316	Phase 2	Active	Washington University School of Medicine	236	2015-01-20 → 2026-08-31
Hormonal Mechanisms of Sleep Restriction - Axis Study NCT03142893	Phase 1	Active	Peter y. Liu	80	2017-05-08 → 2026-06-30
Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia NCT01424982	Phase 2	Active	M.D. Anderson Cancer Center	88	2011-10-05 → 2027-10-31

Source: ClinicalTrials.gov. Trials matched by ingredient name.

VA Federal Supply Schedule

Government-negotiated contract prices | 4 NDCs (2 FSS, 2 Big4)

Lowest Price

$319.26

Highest Price

$5768.26

FSS NDCs

Big4 NDCs

Description	Price	Type	Vendor	Contract End
70382-0204-01DEXTENZA (DEXAMETHASONE 0.4MG IMPLANT,OPH)	$576.82	FSS	Ocular Therapeutix, Inc.	01/31/2027
70382-0204-01DEXTENZA (DEXAMETHASONE 0.4MG IMPLANT,OPH)	$319.26	Big4	Ocular Therapeutix, Inc.	01/31/2027
70382-0204-10DEXTENZA (DEXAMETHASONE 0.4MG IMPLANT,OPH)	$5768.26	FSS	Ocular Therapeutix, Inc.	01/31/2027
70382-0204-10DEXTENZA (DEXAMETHASONE 0.4MG IMPLANT,OPH)	$3083.57	Big4	Ocular Therapeutix, Inc.	01/31/2027

Source: VA Federal Supply Schedule (va.gov). Prices are government-negotiated contract prices.

API Supply Chain11 active DMFs19 inactive

9 active API suppliers hold Drug Master Files for this ingredient.

EUROAPI FRANCEDEXAMETHASONE

DMF 17481971

PHARMACIA AND UPJOHN CO LLC WHOLLY OWNED SUB OF PFIZER INCDEXAMETHASONE USP MICRONIZED

DMF 45241982

TIANJIN TIANYAO PHARMACEUTICALS CO LTDDEXAMETHASONE, USP

DMF 171412004

MAHIMA LIFE SCIENCES PRIVATE LTDDEXAMETHASONE USP

DMF 278882013

FARMABIOS SPADEXAMETHASONE USP

DMF 315322017

TIANJIN TIANYAO PHARMACEUTICALS CO LTDDEXAMETHASONE BULK API

DMF 348102020

XIAN GUOKANG RUIJIN PHARMACEUTICAL CO LTDDEXAMETHASONE

DMF 362702022

SHANDONG SIRUI PHARMACEUTICAL CO LTDDEXAMETHASONE

DMF 368942022

SYMBIOTEC PHARMALAB PRIVATE LTDDEXAMETHASONE USP

DMF 381622023

ZHEJIANG XIANJU PHARMACEUTICAL CO LTDDEXAMETHASONE

DMF 409942024

FARMABIOS SPADEXAMETHASONE MICRONIZED STERILE

DMF 435092026

ORGANON INCInactiveDEXAMETHASONE

DMF 5191963

ORGANON INCInactiveDEXAMETHASONE

DMF 5421963

ORGANON INCInactiveDEXAMETHASONE 21-PHOSPHATE

DMF 5821963

SF DURST AND CO INCInactiveDEXAMETHASONE

DMF 10951967

ORGANON INCInactiveDEXAMETHASONE 21-TERTIARY BUTYLACETATE

DMF 13431969

ANTIBIOTICOS SPAInactiveDEXAMETHASONE, NON-STERILE (BULK)

DMF 22051973

ANTIBIOTICOS SPAInactiveDEXAMETHASONE SODIUM PHOSPHATE BULK

DMF 23781974

ROUSSEL CORPInactiveDEXAMETHASONE SODIUM METASULFOBENZOATE

DMF 27371976

ORGANON INCInactiveDEXAMETHASONE

DMF 28161976

BLASCHIM SPAInactiveDEXAMETHASONE 21 SODIUM PHOSPHATE

DMF 28491977

ANTIBIOTICOS SPAInactiveDEXAMETHASONE 21-SODIUM M-SULFOBENZOATE

DMF 36841980

BLASCHIM SPAInactiveDEXAMETHASONE

DMF 36861980

CYCLO PRODUCTS INCInactiveDEXAMETHASONE

DMF 37331980

COMPANIA ESPANOLA DE SINTESIS QUIMICA SAInactiveDEXAMETHASONE BASE, USP XX

DMF 42851981

COMPANIA ESPANOLA DE SINTESIS QUIMICA SAInactiveDEXAMETHASONE SODIUM PHOSPHATE USP XX

DMF 44971982

DIOSYNTH BVInactiveDEXAMETHASONE MICRO AND NON-MICRO

DMF 49371983

DIOSYNTH BVInactiveDEXAMETHASONE ACETATE MICRO AND NON MICRO

DMF 49441983

SOCIETA ITALIANA CORTICOSTEROIDI SPAInactiveDEXAMETHASONE

DMF 60301985

QUATRUMInactiveDEXAMETHASONE BASE BP/KUSP AS

DMF 62331986

Source: FDA Drug Master Files (fda.gov). Type II API DMFs matched by ingredient.

Approval Letters

5 letters from Drugs@FDA

Date	Submission	Document
Apr 9, 2025	SUPPL -13	View Letter (PDF)
Oct 12, 2021	SUPPL -7	View Letter (PDF)
Mar 4, 2020	SUPPL -5	View Letter (PDF)
Jun 21, 2019	SUPPL -1	View Letter (PDF)
Dec 20, 2018	ORIG -1	View Letter (PDF)

Source: Drugs@FDA application documents.

Products (1)

#001 — 0.4MG

RLD

5 patents1 exclusivity▴

INSERT;OPHTHALMIC | Approved: Nov 30, 2018

Patents (5) · 6 use codes

Patent #	Expiration	PED	Drug Substance	Drug Product	Use Code	Delist
8409606	May 14, 2030	—	—	Yes	—	—
8563027	Feb 12, 2030	—	—	—		—
11458041	Nov 16, 2037	—	—	—		—
12144889	Apr 26, 2041	—	—	—		—
12150896	Oct 7, 2036	—	—	—		—

Exclusivities (1)

Code	Date	Status
NPP	Apr 7, 2028	Active